Type 2 diabetes, Incretins and bone health

A stomach and intestinal hormone called “Incretin” is secreted in response to a meal to help the body metabolize sugar (among other things).    Recent drug therapies have been developed to manipulate this hormone in the treatment of type 2 diabetes.  Either by inhibiting Incretin’s breakdown (dpp4 inhibition, Januvia/Sitagliptan et al.) or stimulating its action (Byetta/Exanitide), insulin secretion can be stimulated or glucagon secretion can be attenuated in response to a glucose load.  A recent paper looked at a novel effect that Incretins may have on bone health.  While still inconclusive, the authors of this study (see link) postulate that Incretins may have a beneficial effect on bone formation and fracture risk.     http://care.diabetesjournals.org/content/34/11/2474.abstract


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